| ncRNA name | BET2 siRNA |
| ncRNA Category | siRNA |
| Disease name | retinitis pigmentosa (RP) |
| Species | Mus musculus |
| Tissues/Cell_line | N9 microglial cells |
| Methods | siRNA transfection, Western blot, qRT-PCR |
| Expression pattern | associated |
| Functional description | BET inhibition rescues photoreceptor degeneration likely via the suppression of microglial activation. siRNA knockdown of BET2 but not BET4, and the inhibitor of Brom2 (RVX208) but not of Brom1 (Olinone), decreased microglial activation. |
| PubMed ID | 28103888 |
| Year | 2017 |
| Title | Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration |
| Drug-related ncRNA | NO |
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